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Description

LIPT1 installs lipoic acid into the subunits of the pyruvate dehydrogenase complex and the -ketoglutarate dehydrogenase complex to maintain the stability of energy metabolism

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To induce oxidative stress, both cell lines were treated with 1-methyl-4-phenylpyridinium (MPP + , a neurotoxic compound that causes mitochondrial dysfunction)

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