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Macrophages polarize to either M1 macrophages or M2 macrophages, and these phenotypes are dependent on the broader environment that the cells are in [146]

& Saharan, S

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The all-trans retinol can convert enzymatically in the dark to the cis form, which is then esterified and stored, presumably among the lipids of epithelial cells

[185] Mounting evidence from postmortem patient tissues suggests a similar gainoffunction of misfolded wildtype SOD1 may contribute to neurodegeneration in sporadic ALS,[ 90b , 165a , 186 ] idiopathic Parkinson's disease, [13] and potentially Alzheimer's disease, [91] although large insoluble misfolded SOD1 deposits are not consistently identified in patient tissues between studies.[ 90a , 90b ] Variation in choice of immunodetection antibodies and methodologies and variation in type and quality of postmortem tissues between research groups likely contributes to the lack of reproducibility of these data