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During these early metabolic changes there are also increases in free radical production by the mitochondria (Step 5), which are increasingly compromised by their attempt to buffer intracellular calcium (Step 8)

Some of the most interesting are those looking at targeting the associated metabolic changes [54,55] , targeting epigenetic changes, using drug associated nano particles [56] , use hypoxia imaging as predictive factor [57] or use of small molecules inhibiting protein-protein interaction to target Hif1 [58]

Increase activity of superoxide dismutase (SOD) is shown in the A-GSH group.[16] T-BARS: T- Bars is a measurement of lipid peroxidation

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