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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

Mechanism of Action 5-Amino-1MQ has been investigated for its selective inhibition of nicotinamide N-methyltransferase (NNMT)

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Key takeaways Vitamin B12 deficiency can cause headaches and may be linked to chronic migraine