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By incorporating protease-cleavable linkers into drug conjugates, it is possible to achieve a high degree of specificity, minimizing off-target effects and enhancing the therapeutic index of the drug

119 Conversely, at the N-terminal domain, a non-catalytic regulatory haem sensor negatively impacts the enzymatic activity of CBS upon reduction and completely inactivates the enzyme upon binding of nitric oxide or carbon monoxide

doi: 10.1016/j.lfs.2019.02.003 193 BouvyCWannezALaloyJChatelainCDogneJM

The gap between doing it right and doing it wrong comes down to three things most guides never mention: precise reconstitution technique, sterile handling throughout every step, and temperature-controlled storage from the moment the vial is opened

Lu, H., Guo, Y., Gupta, G