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Silencing CD147 gene expression increases chemosensitivity in a human ovarian cancer cell line and knockdown of CD147 in MCF7/Adr cells reduces resistance to P-gp substrate drugs [115, 116]

[47] An open-label, randomized study on humans failed to produce a statistically significant protection by N-acetylcysteine in patients of cancer on photodynamic therapy [48] despite animal studies to the contrary

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57 Similarly, the activity of mitochondrial, but not cytoplasmic AST, after ischemic liver injury was reported to be correlated with a decrease of total adenine nucleotides