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29,251 Raffaele et al 252 observed an obvious protective function of EET agonist against diet-induced NAFLD progression, liver fibrosis, and insulin resistance in db/db mice, and that the beneficial effect of EET agonist administration can be abolished by PGC-1

This flexible loop region is located near the substrate-binding site, and is conserved in other Group II decarboxylases

Exactly how this works is unknown, but several studies have indicated that spirulina may help increase insulin sensitivity in both animals and humans ( Insulin sensitivity is a measure of how well your cells respond to the hormone insulin, which shuttles glucose (blood sugar) out of the blood and into cells where it can be used for energy

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From a clinical perspective, investigating the multi-target mechanisms of EW's action will provide stronger scientific evidence for its potential clinical use, positioning EW as a promising adjunctive treatment for ICH