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The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver

However, doctors do not consider low B12 alone a reliable sign of cancer because many non-cancerous conditions can also lower vitamin B12 levels

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Researchers studying obesity, metabolic syndrome, or adipocyte biology often prefer NNMT inhibition over simple precursor supplementation because the effect is concentrated where it matters most