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Acknowledgments This review was supported by the 2024 Talent Project of Shandong First Medical University (045RC200008), and the Taishan Scholars Program (tsqn202211225)

Hoeft K, Schaefer GJL, Kim H, Schumacher D, Bleckwehl T, Long Q, et al

Arato, A., Savilahti, E

CAF-induced physical constraints controlling T-cell state and localization in solid tumors

Accordingly, future research should concentrate on two main areas: (1) Developing innovative strategies, such as exploring alternative gene regulation techniques, engineering feedback-resistant enzymes, and utilizing systems biology approaches to balance growth and production