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2017;12(7):e0181086

10.1021/acsami.9b03519 4 CardanoF.FrasconiM.GiordaniS

doi: 10.1099/ijsem.0.006573 24 MohrKITebbeCC

In humans, we only have observational research, but to date, about 20 studies have followed more than 10 million people over time, and those drinking three cups (720 ml) of coffee a day had 13 percent lower risk of dying from all causes put together

The immunological consequences of these two cell death modalities are fundamentally different: apoptosis is immunologically silent, whereas ferroptosis releases DAMPs such as high mobility group box 1 (HMGB1) and mtDNA, activating the NLRP3 inflammasome and amplifying inflammation (9193)