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Consistent with that hypothesis, we found that acidosis increased p53 protein levels (Figure 5A) and induced the expression of p21 and MDM2 , two well-known p53 target genes (Figure 5B)

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Gene 248:5158 Hatzfeld Y, Maruyama A, Schmidt A, Noji M, Ishizawa K, Saito K (2000b) -Cyanoalanine synthase is a mitochondrial cysteine synthase-like protein in spinach and Arabidopsis

NMDA-Rs also allow influx of Ca 2+ and have thereby a regulatory role in synaptic plasticity by connecting synaptic activity with Ca 2+ -mediated biochemical signaling [31]