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Numerous studies also proved that ER stress contributes to intestinal inflammation diseases via the activation of IRE1/ATF6-XBP1 signaling pathway (1214)

It has been evident that CD44 as a surface biomarker of cancer stem cells (CSCs) and a vital regulatory factor of epithelial-mesenchymal transition (EMT) program is involved in the regulation of tumor initiation and development [6, 15,16,17]