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(2021) 11:CD001145

Unsupervised hierarchical cluster analysis and supervised orthogonal partial least squares discriminant analysis (OPLS-DA) were performed using the Metaboanalyst 5.0 web server 45 (accessed on August 2022) Variable Importance in Projection (VIP) scores greater than 1 was considered to select relevant variables in the models 46

Polymorphic site substitutions present in 2 participants in the study were observed in 10, 6, 18, 8 and 6 participants at Weeks 192, 240, 288, 336 and 384, respectively