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Given the characteristics of short-lived free radical species, which are challenging to confirm as transferring between cells through gap junctions after APAP overdose, we employed a thioacetamide-induced hepatotoxicity model

Mitochondria are also involved in key cellular functions such as Ca 2 + homeostasis, heme biosynthesis, nutrient metabolism (Renault and Chipuk, 2013)

Other experimental studies in vivo [65,66] have shown that GSH molecular pathways are increased, although not always significantly, after sulforaphane, a cruciferous-derived compound, administration [65]