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doi: 10.1074/jbc.272.48.30371

Furthermore, CHAC1 negatively regulates the NOTCH1 receptor, a key player in determining cell fate, particularly in neuronal stem cells, affecting their development and differentiation ( 2.1 CHAC1 upregulation under arsenite stress and amino acid depletion As a stress-responsive protein, CHAC1 is critically involved in the cellular stress response