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10.1016/j.chembiol.2004.03.009

Dysregulation of ERAD can lead to an accumulation of misfolded proteins in cardiomyocytes, contributing to the pathogenesis of heart disease

Glioblastoma-derived IL-6 induces immunosuppressive peripheral myeloid cell PD-L1 and promotes tumor growth

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This adaptive capacity is further complicated by the dynamic and heterogeneous nature of the AML epigenome, which varies both between patients and within individual patients over disease progression (Stelmach and Trumpp, 2023)