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There are 34 known MTHFR mutations that can occur in humans, which result in MTHFR enzymes that range from being almost as effective as the wild type (non-mutated) to significantly less effective (for example, an enzyme that is 25% as effective as the wild type)

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Journal of Molecular Endocrinology, 52 (1), R107-R123

For patients in that second category, peptide therapy is increasingly part of the conversation, and two compounds come up most often: BPC-157 and TB-500