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doi: 10.3390/antiox12051117 36

it demonstrated preclinical efficacy (80), progressed to first in human testing, and showed activity in Ras driven models, including combinational benefit with platinum therapy (81, 82)

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Gastrointestinal discomfort, including mild nausea or stomach upset, has been noted in anecdotal accounts, though no severe gastrointestinal effects have been documented in controlled studies

Athira Pharma's fosgonimeton (ATH-1017), part of the same HGF/c-Met program, failed the primary endpoint of its Phase 2/3 LIFT-AD Alzheimer's trial in September 2024