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Western blot analysis Samples were resuspended in 6x Laemmli buffer and loaded onto an SDS-PAGE for protein separation, followed by transfer to a nitrocellulose membrane with the wet blot method

JAK pathway targeting presents therapeutic potential for addressing SASP-mediated inflammation and frailty in aging populations (422), driving research into SASP-modulating therapeutic approaches including senolytic and senomorphic compounds (423)

Because it looks a lot like the neurotransmitter acetylcholine, it gets involved in brain metabolism, potentially boosting acetylcholine production and helping build proteins and membrane phospholipids

Replacement of the conserved asparagine by alanine resulted in constitutive p300 interaction and strong transcriptional activity