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It has been also demonstrated that molecules involved in bacterial quorum-sensing such as indole and its derivative, indole-3-acetonitrile (IAN) were able to significantly alleviate the virulence of C

In addition, deletion of the GSH1 geneencoding -glutamylcysteine synthetase (-GCS), the enzyme catalysing the first step in glutathione synthesiswas shown to suppress an Ero1 conditional mutant, again indicating that GSH provides an additional load on Ero1 activity (Frand & Kaiser, 1998)