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Blood Adv 10(9):3276-3280, 2026

reported that lower GPX3 activity during both the early and late stages of pregnancy is independently linked to a greater risk of gestational DM and greater gestational age [147]

10.1007/s00299-012-1338-5 134 ThomasD

Moreover, GPX3 deficiency also led to the downregulation of Nrf2, a negative upstream regulator of ferroptosis, suggesting that the antagonistic effect of GPX3 on ferroptosis in prostate cells was related to Nrf2