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The pathological changes could also include altered brain metabolism, excitotoxicity, free radical generation, neuroinflammation, blood-brain barrier dysfunction, and apoptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Cardoso F.D.S., Salehpour F., Coimbra N.C., Gonzalez-Lima F., Gomes da Silva S

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Over three decades ago, John Bienenstock proposed the concept of a common mucosal immune system, suggesting that the mucosal immune system itself is an organ where mucosal immune cells distributed throughout the body can interact across different mucosal tissues and organs 55