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3.3 Effects of metformin on angiogenesis in endometriosis Angiogenesis is fundamental to the growth of endometriotic tissue, which starts with the destabilization of the pre-existing vasculature, and is driven by the release of pro-angiogenic factors and the degradation of the extracellular matrix (ECM)

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It is generally believed that chloasma has much to do with sun exposure, but UV is not always necessary for the development of chloasma and there are other factors involved in promoting its development (142)

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Treatment of SUD is a long-term process, and it may be more effective to consider SUD as a chronic disease and to treat them in combination with multiple supporting approaches

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85 NguyenT

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