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Confusingly enough, cuprizone also does not kill oligodendrocytes in vitro [111], suggesting that cuprizone alone might not be enough to induce oligodendrocyte cell death in vivo

Due to the complexity of serotonin's role in migraine, further study is needed to fully characterize the effects of modulating serotonin levels and/or signaling in migraine patients

The expression levels of Kim-1 and NGAL were increased 4 to 5-fold in the kidneys, resulting in significant nephrotoxicity

Have severe or unstable medical conditions (e.g., uncontrolled diabetes, end-stage renal disease, significant heart or liver disease) without first consulting a physician

However, there is insufficient evidence indicating that holistic management of glycemia and other risk factors can alleviate the neuropathic pain