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Support came from National Institutes of Health grants AI4782, AI120500, AI007051, DK082227 and GM008861

HEK-293T were from American Type Culture Collection (ATCC), and cultured in Dulbeccos modified Eagles medium (DMEM) (Cytiva, SH30003.02) supplemented with 10% fetal bovine serum (FBS, Cytiva)

[DOI] [PubMed] [Google Scholar] 96.trba M, Popelov O, Vvrov A, Jirkovsk E, Kovakov P, Gerl V, imnek T: Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

Histone post-translational modificationscause and consequence of genome function

Marine polysaccharides such as fucoidan exhibit strong anti-inflammatory and immunomodulatory activity by inhibiting NF-B signaling and downregulating TNF-, IL-6, and IL-8 (132)