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Ethanol may have the capacity to elevate the activity of nicotinamide adenine dinucleotide phosphate oxidase (NOX) or NADPH Oxidase enzymes, which, in turn, can lead to the formation of ROS [180]

Murakami M, Osada K, Mizuno H, Ochiai T, Alev L, Nishioka K (2015) A randomized, double-blind, placebo-controlled phase III trial of duloxetine in Japanese fibromyalgia patients

Nilius, J.G

5e and f)

These four mechanisms operate on distinct molecular targets, which minimizes theoretical pathway competition and provides the rationale for multi-component research models