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doi:10.1038/nri1529

Finally, the absence of validated biomarkers for predicting treatment response or monitoring efficacy further complicates both clinical research and practical application, limiting the ability to personalize therapy or objectively assess outcomes

It is expected that at the end of the DSRIP program, the health care delivery system for Medicaid members and other New Yorkers will look fundamentally different, with greater focus on high quality ambulatory care and a de-emphasis on hospital inpatient and ED care, helping to meet the state goal of reducing avoidable hospital use, including emergency department and inpatient, by 25%

It has, however, been linked to alterations in the hypothalamic-pituitary-adrenal axis

393,394 Thus, the mechanisms underlying the regulatory role of SIRT1 in DNA repair and gene transcription in cancer development need further exploration