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GSH directly reacts with superoxide, NO, peroxynitrite, and hydroxyl radical

In an earlier cohort study involving 52 -thalassemia patients with HF, who received chelation therapy in combination with standard anti-heart failure treatment had a survival rate of approximately 50% over a 5-year period, comparable to other HF patients (194)

These findings suggest that targeting PLD could be a key strategy to disrupt the crosstalk between ferroptosis and pyroptosis (165)

subsequently, as it passes through the ER-Golgi intermediate compartment (ERGIC) and Golgi apparatus, STING recruitment of TANK binding kinase 1 (TBK1) promotes TBK1 autophosphorylation (141, 144, 145)

doi: 10.1056/nejmoa041588