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To reduce redundancy in GOBP ORA, GO terms with more than 85% gene overlap were eliminated, ensuring a Jaccard index close to 1

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ABPW1 Achyranthes bidentata polysaccharide ACE Angiotensin-Converting Enzyme ADMA Asymmetric dimethylarginine AhR Aryl hydrocarbon receptor AKI Acute Kidney Injury Akt Protein Kinase B AQP2 Aquaporin-2 ARE Angiotensin II Receptor Blocker ASC Apoptosis-associated speck-like protein containing a CARD BCRP Breast cancer resistance protein BUN Blood urea nitrogen CAM Complementary and Alternative Medicine CFU Colony forming unit CKD Chronic Kidney Disease Col1a1 Collagen type I alpha 1 chain COX-2 Cyclooxygenase-2 CRP C-reactive protein CRS Cardiorenal Syndrome CYP1A1 Cytochrome P450 1A1 DAO Diamine oxidase DF Dietary fiber DN Diabetic nephropathy EAA Essential amino acid ECM Extracellular matrix eGFR Estimated glomerular filtration rate ENaC Epithelial Sodium Channel eNOS Endothelial Nitric Oxide Synthase ESRD/ESKD End-stage renal disease/End-stage kidney disease F/B Firmicutes/Bacteroidetes FMT Fecal microbiota transplantation FOXO3a Forkhead Box O3a FSGS Focal Segmental Glomerulosclerosis FTZ Fufang Zhenzhu Tiaozhi Capsules FTZP FTZ Polysaccharides GCA Glycocholic acid GFR Glomerular filtration rate GG Guar Gum GPR43 G protein-coupled receptor 43 HIA Hippuric Acid HO-1 Heme Oxygenase-1 IAA Indole-3-acetic acid IDO Indoleamine 2,3-Dioxygenase IgAN IgA nephropathy IgAV-N IgA vasculitis with nephritis IKK IB kinase IL-1/6/10/17 Interleukin-1/6/10/17 IMN Idiopathic Membranous Nephropathy iNOS Inducible Nitric Oxide Synthase IRE1 Inositol-requiring enzyme 1 IS Indoxyl sulfate JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated Protein 1 LN Lupus Nephritis LPD Low-protein diet LPS Lipopolysaccharide MAPK Mitogen-activated protein kinase MCD Minimal Change Disease MN Membranous Nephropathy MRP2/4 Multidrug resistance-associated protein 2/4 MSG Moshen Granule MsPGN Mesangial proliferative glomerulonephritis mTOR Mechanistic Target of Rapamycin NADPH Nicotinamide adenine dinucleotide phosphate NF-B Nuclear factor kappa B NH Ammonia NLRP3 NOD-like receptor family pyrin domain containing 3 Nrf2 Nuclear Factor Erythroid 2Related Factor 2 NO Nitric oxide OAT1/3 Organic anion transporter 1/3 OCT2 Organic cation transporter PAG Phenylacetic acid PAMPs Pathogen-Associated Molecular Patterns PCS/PS p-Cresyl sulfate PD Peritoneal Dialysis PERK PKR-like ER kinase PHGG Partially hydrolyzed guar gum PI3K Phosphoinositide 3-Kinase PU Punicalagin QDTS QiDiTangShen Granules RCT Randomized controlled trial ROS Reactive oxygen species RS Resistant starch SCFA Short-chain fatty acid SBA Secondary bile acid SIRT3 Sirtuin 3 SP Sodium propionate STAT3 Signal Transducer and Activator of Transcription 3 SZP Sanzi Guben Polysaccharides TCA Tricarboxylic acid TCDCA Taurochenodeoxycholic acid TCM Traditional Chinese Medicine TCPM Traditional Chinese Patent Medicine TDO Tryptophan 2,3-Dioxygenase TGF-1 Transforming growth factor beta 1 TLR Toll-like receptor TMA Trimethylamine TMAO Trimethylamine N-oxide TNF- Tumor necrosis factor alpha YQHG Yishen Qingli Heluo Granule YSHS Yi-Shen-Hua-Shi Granule ZO-1 Zonula occludens-1 Glossary References 1 AhmedL