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Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2

However, complications such as hypothyroidism, anemia, depression or any other reasons for fatigue have to be carefully excluded rather than assuming PBC to be the cause, particularly as these complications may be treatable

J Neurogastroenterol Motil 23, 453463

In two previous clinical trials, the combination use of vitamin B12 (500 g/day) and folic acid (5 mg/day) for about eight weeks led to a significant improvement in FBG levels and HOMA-IR 41,42

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