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[Also published as DREW (NIH) 781336 by the National Institute of Health, Bethesda, MD]

These cells can also produce interleukin-21 and express the transcription factor B cell lymphoma 6 (BCL-6)

1 Stored primarily in the liver, vitamin B12 plays an important role in several essential bodily functions, including: 2 DNA synthesis Healthy red blood cell formation Central nervous system development and function Enzyme function Interest in vitamin B12s role in long-term health has grown in recent years not only because it helps support neuron function, learning, and memory, but also because some research has explored whether elevated vitamin B12 levels may be associated with certain cancers

Furthermore, many patients are refractory to available therapeutic drugs, which work primarily by increasing the levels of the monoamine neurotransmitters serotonin and norepinephrine in the synaptic cleft

The prevalence of low back pain: a systematic review of the literature from 1966 to 1998