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And yet the therapies have attracted enormous attention in the wellness space

Taketa T, Xiao L, Sudo K, Suzuki A, Wadhwa R, Blum MA, Lee JH, Weston B, Bhutani MS, Skinner H, Komaki R, Maru DM, Rice DC , Swisher SG, Hofstetter WL, Ajani JA

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further elucidated the underlying mechanism through in vitro experiments, showing that berberine inhibits morphine-induced activation of BV2 cells, suppresses NF-B signaling to reduce the release of pro-inflammatory cytokines, and mitigates morphine-induced apoptosis by regulating apoptosis-related proteins, including upregulating Bcl-2 and downregulating Bax and Caspase-3 ( Bulleyaconitine A (BLA, C 35 H 49 NO 9 ) is a C19-diterpenoid alkaloid isolated from Aconitum bulleyanum Diels., known for its potent analgesic activity (Zhao et al., 2021)

Expression of genes encoding alanine transporters in the cARLA-treated human co-culture model of BBB are shown from our previously published dataset publicly available at the Gene Expression Omnibus (GEO) under accession number GSE224846 [40]