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Conclusions High levels of OS can be considered a result of the imbalance between oxidative species and antioxidant defense systems, and indeed represent a hallmark of many acute and chronic diseases, including ALS

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DFO, the most widely used iron chelator approved by the FDA, inhibits lipid peroxide chelation by inhibiting the Fenton reaction, and one study found that DFO effectively protects neurons by increasing the expression of hypoxia-inducible factor 1 (HIF-1