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In the blood, MEL binds to albumin and in the liver, it is metabolized to 6-hydroxymelatonin by cytochrome P450 isoforms (mainly CYP1A2) and conjugated to 6-sulfatoxymelatonin, which is then excreted in the urine, and its concentration reflects the plasma concentration and can be used to assess pineal function

When delivered within three hours after symptom onset, rt-PA reduces neurological deficits and improves the functional outcome of stroke patients

Ni J, Li Y, Xu Y, Guo R

Uemura T, Yerushalmi HF, Tsaprailis G, et al