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However, the in vivo metabolic behavior and biocompatibility of GSH-CDs still require further and longer-term research and verification

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Elevated HMGB1 levels serve as a significant marker of SCZ

This indicates that longer exposure to hydrogen, or different concentrations may have a more beneficial effect, or that hydrogen may only be effective in mild cases of brain injury [46]

Mechanistically, gut microbiota-derived SCFAs exert their functions by activating trans-membrane G-protein-coupled receptors (GPCRs) of GPR41 and GPR43 or inhibiting histone acetylation (HDAC) to directly enter host cells (Moniri and Farah, 2021)