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Non-alcoholic fatty liver disease: Pathogenesis and clinical features NAFLD is the most common liver disease, characterized by an excessive hepatic fat accumulation in the absence of alcoholic abuse, steatogenic medications or others concomitant liver diseases (2)

because the cytokine activity is induced by ROS and leads to fibrosis [10,11], this implies that in a pro-fibrogenic environment, the depletion of GSH occurs through multiple mechanisms, either by oxidation or by decreased synthesis [12]

Dysregulation of KEAP1-NRF2 activity has been observed in ALS cellular and animal models, and confirmed in human ALS tissue [67, 141, 243]

Vlahakis, A., Lopez Muniozguren, N

Dissecting DNA hypermethylation in cancer