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Subsequently, OPN induces tumor cells to produce TGF- , which in turn upregulates PD-1 expression on immune cells and ultimately increases the sensitivity of breast cancer to PD-1 immunotherapy

It is involved in the synthesis of thymidine from deoxyuridine, promotion of deposited folate utilisation and metabolism of nucleic acid

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Total RNA was incubated in DNase I RNase-free (Roche Applied Science)

14.4%), which means the investigators had not updated the records for at least 2 years and the expected completion time had passed