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muHTT aggregates sequester a wide variety of proteins essential for cell homeostasis, including chaperones and transcription factors, and their depletion may contribute to HD pathogenesis

The phosphorylation of p38 activates MITF expression, which up-regulates melanogenesis-related proteins and stimulates melanin synthesis [37,38]

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Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function.Eur J Clin Nutr

For instance, minimal change disease exhibits proteinuria, normal to increased creatinine, and podocyte injury in a light microscopy assay (101)