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359 This reduction in ROS can inhibit autophagy in IVDs and reduce the apoptosis of myeloid cells caused by oxidative stress, maintaining the stability of the structure of IVD

Plotted from data in J Am Soc Nephrol 2006

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Examples of methods for quantifying common reactions include: Lipid Oxidation/Rancidity Peroxide values Tbar values Oxygen consumption Sensory Browning Reactions Color changes Sensory Formation of reaction products Vitamin Loss Test kits (ELISA) HPLC While there are examples of shelf life models in the literature, the only fundamental model that includes both water activity and temperature is hygrothermal time (7)

A previous comparison of degenerated and herniated disc tissues showed the latter to have greater GAG loss, neovascularisation, innervation, cellularity, and expression of MMPs than discs that degenerated without herniating 21