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Author response: We have corrected the phrasing in these lines to be more accurate

CoolTone induces muscle contractions to enhance muscle function and may, therefore, be considered a method of muscle training Relaxation of muscle spasms, preventing or slowing muscle weakness due to lack of use, increasing blood flow to a specific area, retraining muscles, and maintaining or increasing the range of motion Use under medical supervision with other therapies for treating certain medical diseases and conditions Stimulating leg muscles for rehabilitation therapy Important Safety Information The CoolTone procedure is not suitable for everyone

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Longevity pathways activated NAD+-dependent enzymes like SIRT1, tied to DNA repair and stress response, become more active

| supplement ingredients manufacturer Product Parameters Product introduction 5-Amino-1-methylquinolinium chloride is an enzyme overexpressed during skeletal muscle aging and is associated with repair of NAD+ pathway damage, dysregulated sirtuin1 activity, and increased muscle stem cell senescence