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Soluble factors include the complement, acute-phase proteins, and cytokines [30]

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A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)

GHK-Cu and Skin / Wound Healing GHK-Cu has been extensively investigated in skin-derived cell cultures and animal models focused on tissue repair: Extracellular Matrix Modulation: Studies in skin cultures indicate that GHK can stimulate both synthesis and controlled breakdown of collagen, glycosaminoglycans, and proteoglycans such as chondroitin sulfate

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