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This binding triggers intracellular cAMP signaling cascades that upregulate GH gene expression and stimulate the exocytosis of stored growth hormone

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Tumor necrosis factoralpha (TNF-a) and interleukin-1b (IL-1b) are the examples of some important proinflammatory cytokines whose expression was downregulated by GLE in a dose-dependent manner and can be treated by natural antibiotics reported in [81]