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Burette AC, Judson MC, Li AN, Chang EF, Seeley WW, Philpot BD, et al

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A pilot study of oral therapy with a 5-LOX inhibitor (zileuton) for AD demonstrated that the compound prevented disease exacerbations and prolonged remission, confirming the functional role of LTB 4 in the development of this disease [229]

Moreover, the low inhibitory effect of HQ was also evident in another kinetic study with mushroom tyrosinase that exhibited an IC 50 value 80-fold higher when L-dopa was used, in comparison to L-tyrosine 24