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Fundamental questions remain regarding the future prospects of this line of drug development, including questions concerning safety and tolerability, efficacy, doseresponse relationships and therapeutic mechanisms

[11] Bile-acid sequestrants and orlistat impair intestinal absorption of fat-soluble vitamins, explaining why some patients switch to parenteral therapy, whereas magnesium-containing antacids and digoxin can synergise with vitamin D to provoke hypermagnesaemia or digitalis toxicity if calcium rises unchecked

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Not strictly required, but useful