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Besides, IH could promote neuronal apoptosis in normal mice and diabetes mice models, the latter had higher apoptosis levels and could be modulated by high mobility group box-1 protein (HMGB1)/toll-like receptor 4 (TLR4) signal [53]

Three clinically validated prescriptions, such as Cong Rong Shu Jing Granules and Chaihu Jia Longgu Muli Decoction, demonstrate these synergistic effects

HbA1c variability as an independent correlate of nephropathy, but not retinopathy, in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian multicenter study

& Gray, K

ChaC1 is upregulated under stress conditions such as ER stress and amino acid starvation [105], whereas ChaC2 is constitutively expressed and may act in a housekeeping fashion [5]