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Contrave, designed for oral administration, has variable bioavailability: naltrexone reaches about 96% bioavailability, while bupropion achieves approximately 87% bioavailability when taken with food

In comparing the two formulations, the Sucrosomial B12 group consistently exhibited higher circulatory vitamin B12 levels at every post-treatment timepoint ( p 0.029) (Figure 4 boxplots, bottom)

PMID 12788900

While many people get enough Vitamin B12 from their diet, some may require supplementation due to deficiencies caused by various factors like food restrictions, medical conditions, or age

There is no definitive evidence that B12 is better absorbed at a specific time of day