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These immune cells interact with hepatocytes and nonparenchymal liver cells, orchestrating an intricate inflammatory response through the secretion of various mediators [45]

In addition, eNAMPT may act biochemically by metabolizing extracellular nicotinamide into NMN, which may diffuse into the cell, restoring the parental phenotype

Sasaki M, Bharwani S, Jordan P, Joh T, Manas K, Warren A, et al

Galimberti D, Scarpini E, Venturelli E, Strobel A, Herterich S, Fenoglio C, Guidi I, Scalabrini D, Cortini F, Bresolin N, Lesch K-P, Reif A (2008) Association of a NOS1 promoter repeat with Alzheimers disease