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Homozygous and mutated SLC19A3 gene can cause various conditions such as biotin-thiamine responsive basal ganglia disease (BTBGD), lactic acidosis combined with encephalopathy, infantile epileptic spasms, and early childhood encephalopathy induced by disease or trauma

B12 functions as a cofactor in cellular metabolism but does not directly cause fat reduction or appetite suppression

Analogously, Baales-Luna et al (Baales-Luna et al., 2020)

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Preclinical models used oral dosing at 50100mg/kg body weight, but human-equivalent subcutaneous protocols typically range from 30mg to 50mg per injection, administered once daily