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Addressing these limitations will be crucial in translating this approach into a clinically viable therapy

Ionic strength modulates the electric double layer thickness, influencing the electrostatic repulsion between particles, while temperature variations can shift the thermodynamic equilibrium, favoring either hydrogen bonding (at lower temperatures) or hydrophobic interactions (at higher temperatures)

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Damage to pre-oligodendrocytes and hypomyelination is unlikely to be solely due to autonomous cell-intrinsic vulnerability