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When MT levels are sufficient, the metal is removed from the MTI, allowing it once again to bind to MTF-1, thereby inhibiting transcription (Morby et al., 1993)

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and c) at antral follicular stage, IGF-I may increase follicle sensitivity to gonadotrophin, oocyte maturation and LH-R expression in granulose and theca cells enhancing their proliferation and steroidogenic activity[107111]

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Despite several advances, unresolved issues include the impact of protumorigenic and antitumorigenic mechanisms in different cell types and the mechanisms by which the antioxidant transcription factor network functions at various stages of tumorigenesis